How is dose calculation typically performed for rodents in mg/kg, and what factors influence accurate dosing?

• A. Dose equals mg per kg body weight; relies on rough weight estimates and generalized PK across species.
• B. Dose is determined by target concentration in blood regardless of weight.
• C. Dose equals weight in mg times body surface area.
• D. Dose equals the desired mg per kg body weight; requires accurate body weight, species-specific pharmacokinetics, route of administration, and consideration of weighing stress.

Answer: (D)